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APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division

Lookup NU author(s): Dr Alexandra Reis, Dr Mark Levasseur, Professor Keith Jones


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Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APC(cdh1) is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APC(cdh1) is active in mouse oocytes and is necessary to maintain prophase arrest.

Publication metadata

Author(s): Reis A, Chang HY, Levasseur M, Jones KT

Publication type: Article

Publication status: Published

Journal: Nature Cell Biology

Year: 2006

Volume: 8

Issue: 5

Pages: 539-540

ISSN (print): 1465-7392

ISSN (electronic): 1476-4679

Publisher: Nature Publishing Group


DOI: 10.1038/ncb1406


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Funder referenceFunder name
065354Wellcome Trust
075744Wellcome Trust