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Lookup NU author(s): Professor David GrahamORCiD
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Understanding contaminant fate requires knowledge of the mechanisms by which a compound is degraded, including the rate at which it is transformed as well as the structures of the various products produced. This need to identify and characterize at the molecular level contaminant transformation products at the molecular level introduces a number of unique analytical challenges. Because of the high information content provided by NMR spectroscopy, it is an attractive method for the study of contaminant transformation, especially when combined with analysis by mass spectrometry. The versatility of HPLC-NMR makes it a robust and efficient method for the identification of components of complex mixtures, such as those encountered in the study of environmental contaminants. The role of HPLC-NMR as a tool for environmental analyses is discussed and its utility is illustrated by examples from our work to understand the transformation of the fluoroquinolone antibiotic ciprofloxacin. Recent technological advances to improve sensitivity such as the coupling of sample concentration by capillary isotachophoresis allow NMR spectroscopy to play an increasingly important role in studies of the fate of emerging contaminants.
Author(s): Cardoza LA, Almeida VK, Carr A, Larive CK, Graham DW
Publication type: Article
Publication status: Published
Journal: TrAC Trends in Analytical Chemistry
Year: 2003
Volume: 22
Issue: 10
Pages: 766-775
Print publication date: 01/11/2003
ISSN (print): 0165-9936
ISSN (electronic): 0167-2940
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/S0165-9936(03)01012-4
DOI: 10.1016/S0165-9936(03)01012-4
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