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Thyroid stimulating immunoglobulins and control of thyroid function

Lookup NU author(s): Gwyn Pyle, Dr Joyce Nutt


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Triiodothyronine (T3) suppression and thyrotropin-releasing hormone (TRH) tests were used to study thyroid function in 50 patients with thyroid disease. The results of the thyroid function tests were compared with the levels of serum thyroid-stimulating immunoglobulins (TSI) measured by a radio-receptor assay. In euthyroid and hyperthyroid patients, the presence of TSI corresponded with the absence of TSH control of thyroid function. However, in two hypothyroid patients with serum TSI levels readily detectable in the receptor assay, T3 suppression and TRH tests indicated that thyroid function was under TSH control.

Publication metadata

Author(s): Clague R, Mukhtar ED, Pyle GA, Nutt J, Clark F, Scott M, Evered D, Smith BR, Hall R

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Endocrinology and Metabolism

Year: 1976

Volume: 43

Issue: 3

Pages: 550-556

Print publication date: 01/01/1976

ISSN (print): 0021-972X

ISSN (electronic): 1945-7197

Publisher: The Endocrine Society


DOI: 10.1210/jcem-43-3-550


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