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Invariable chain (Ii-chain) as a highly important molecular chaperone of histocompatibility class II molecules

Lookup NU author(s): Dr Alexei von Delwig


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Review. The publications on the structural and functional features of the main molecular shaperon of li-chain were updated. In the 1990s the determination of molecular shaperon as a group of mutually unrelated protein molecules taking part in the assembly of other polypeptides was worked out. In humans the main isoform of li-chain is the protein with a mol. wt. of 31-33 kD. A great variety of functions of this shaperon is linked with definite amino acid sequences. In particular, the molecular shaperon of the molecules of the main histocompatibility complex-II has functions connected with the presentation of antigen and the differentiation of B lymphocytes

Publication metadata

Author(s): Delvig AA; Semenov BF

Publication type: Article

Publication status: Published

Journal: Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii

Year: 2004

Issue: 2

Pages: 99-106

Print publication date: 01/03/2004

ISSN (print): 0372-9311

Publisher: Izdatel'stvo S-Info

PubMed id: 15188575