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Intestinal permeability in children with Crohns disease and celiac disease

Lookup NU author(s): Professor Andrew Pearson, Dr Michael Laker, Emeritus Professor Alan Craft, Dr Robert Nelson


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Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.

Publication metadata

Author(s): Pearson, A. D. J., Eastham, E. J., Laker, M. F., Craft, A. W., Nelson, R.

Publication type: Article

Publication status: Published

Journal: British Medical Journal - Clinical Research Edition

Year: 1982

Volume: 285

Issue: 6334

Pages: 20-21

Print publication date: 03/07/1982

ISSN (print): 0959-8138

ISSN (electronic):


DOI: 10.1136/bmj.285.6334.20

PubMed id: 6805795


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