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Lookup NU author(s): Professor Andrew Pearson, Dr Michael Laker, Emeritus Professor Alan Craft, Dr Robert Nelson
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Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.
Author(s): Pearson, A. D. J., Eastham, E. J., Laker, M. F., Craft, A. W., Nelson, R.
Publication type: Article
Publication status: Published
Journal: British Medical Journal - Clinical Research Edition
Year: 1982
Volume: 285
Issue: 6334
Pages: 20-21
Print publication date: 03/07/1982
ISSN (print): 0959-8138
ISSN (electronic):
URL: http://dx.doi.org/10.1136/bmj.285.6334.20
DOI: 10.1136/bmj.285.6334.20
PubMed id: 6805795
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