Browse by author
Lookup NU author(s): Emeritus Professor Alan Craft
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Gas chromatography with flame ionisation detection has been used to establish the normal urinary excretion values of homovanillic acid and 4-hydroxy-3-methoxymandelic acid in 808 infants aged 6 months. This study, the essential pre-requisite for population screening for neuroblastoma in babies, reveals a mean homovanillic acid of 10.9 mumol/mmol creatinine and mean 4-hydroxy-3-methoxymandelic of 6.8 mumol/mmol creatinine. The upper 95% confidence interval were 25.5 mumol/mmol creatinine for homovanillic acid and 15.0 mumol/mmol creatinine for 4-hydroxy-3-methoxymandelic. Gas chromatography/mass spectrometry analysis of the 39 samples, (4.8%) with apparent increased excretion of one or both metabolites, revealed that this was, in each case, due to interfering peaks on chromatography.
Author(s): Dale, G., McGill, A. C., Seviour, J. A., Craft, A. W.
Publication type: Article
Publication status: Published
Journal: Annals of Clinical Biochemistry
Year: 1988
Volume: 25
Issue: Part 3
Pages: 233-236
Print publication date: 01/05/1988
ISSN (print): 0004-5632
ISSN (electronic):
PubMed id: 3400977
