ePrints

A preliminary study of serum class II levels in healthy individuals and bone-marrow transplant patients

Lookup NU author(s): Sue Thompson, Professor Andrew Pearson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

A double-determinant ELISA has been developed to measure class II major histocompatibility complex molecules in blood from healthy individuals and patients who received either an allogeneic or an autologous bone-marrow transplant. Levels were higher in pre-transplant patients than in healthy individuals, and in the majority of patients, these levels rose even higher at 4 weeks post-transplantation. At later times after transplantation, it was difficult to draw firm conclusions, because the number of values available were too limited. Nevertheless, in the autologous group with no graft-versus-host disease (GVHD), levels were consistently lower at 6 months and one year; in the allogeneic group these long-term levels varied. As class II antigens are expressed on skin and rectal epithelia in GVHD, this study suggests that serial measurement of serum class II levels may be useful for monitoring GVHD in bone-marrow transplantation.

Publication metadata

Author(s): Thompson S, Wareham M, Pearson ADJ, Sviland L, Turner GA

Publication type: Article

Publication status: Published

Journal: Clinica Chimica Acta

Year: 1989

Volume: 185

Issue: 1

Pages: 45-52

Print publication date: 01/10/1989

ISSN (print): 0009-8981

ISSN (electronic): 1873-3492

URL: http://dx.doi.org/10.1016/0009-8981(89)90129-0

DOI: 10.1016/0009-8981(89)90129-0

PubMed id: 2620453

Altmetrics

Share