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Pulmonary function in survivors of wilms' tumor

Lookup NU author(s): Emeritus Professor Alan Craft


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The respiratory status of 47 patients surviving childhood Wilms' tumor was studied. The group that had received flank irradiation (which impinges on the lower lung) (n = 17) had a significantly lower mean percent predicted for forced expiratory volume in one second, residual volume, and total lung capacity when compared to those who had received no irradiation (n = 23). Those patients who had received whole-lung irradiation (n = 3) had significantly lower transfer factor for carbon monoxide and gas transfer per unit lung volume when compared to the nonirradiated group (n = 23). There was no significant difference in the prevalence of respiratory symptoms between the three groups. Patients receiving any form of radiotherapy for Wilms' tumor may have abnormalities of pulmonary function and should have pulmonary function tests performed as part of their long-term follow-up.

Publication metadata

Author(s): Shaw, N. J., Eden, O. B., Jenney, M. E. M., Stevens, R. F., Morrisjones, P. H., Craft, A. W., Castillo, L.

Publication type: Note

Publication status: Published

Journal: Pediatric Hematology and Oncology

Year: 1991

Volume: 8

Issue: 2

Pages: 131-137

Print publication date: 01/04/1991

ISSN (print): 0888-0018

ISSN (electronic): 1521-0669

URL: http://dx.doi.org10.3109/08880019109033440

DOI: 10.3109/08880019109033440

PubMed id: 1650574