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21-day schedule oral etoposide in children--a feasibility study

Lookup NU author(s): Professor Andrew Pearson

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Abstract

To determine the feasibility and toxicity of prolonged oral etoposide in children, 22 patients with relapsed or refractory disease: were commenced on etoposide 50-100 mgs/m(2) per day for 21 days. A second course was administered after full blood count recovery, followed by disease reassessment. In total, 72 courses were evaluable for toxicity, with 10% of completed courses complicated by febrile neutropenia. 15 patients were evaluable for response, with 1 partial response, 10 stable disease and 4 progressive disease. This schedule was well tolerated with acceptable toxicity when doses of less than 80 mg/m(2)/day were administered and warrants further evaluation.

Publication metadata

Author(s): Davidson A, Lewis I, Pearson ADJ, Stevens MCG, Pinkerton CR

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 1993

Volume: 29A

Issue: 16

Pages: 2223-2225

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852

URL: http://dx.doi.org/10.1016/0959-8049(93)90210-7

DOI: 10.1016/0959-8049(93)90210-7

PubMed id: 8110489

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