Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Dopamine metabolism in postmortem caudate-nucleus in neurodegenerative disorders

Lookup NU author(s): Emeritus Professor Elaine Perry, Emeritus Professor Robert PerryORCiD, Professor Ian McKeith, Dr Andrew Fairbairn

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Concentrations of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the ratios of these to dopamine(DA) and 5-hydroxyindoleacetic acid(HIAA) in the caudate nucleus of patients affected with Alzheimer's disease Senile Dementia of Lewy body type(SDLT) and Parkinson's disease were determined. Each disorder had a unique pattern of dopamine metabolism when compared with normals. Patients with Alzheimer's disease had a high ratio of DOPAC/DA and a low ratio of HIAA/DOPAC whereas in Parkinson's disease the high DOPAC/DA ratio was associated with low concentrations of DA and its metabolites. Low concentrations of DA and its metabolites in caudate also differentiated SDLT from controls and Alzheimer's disease In addition, hallucinations in SDLT were associated with a low ratio of DOPAC/DA.

Publication metadata

Author(s): Marshall EF, Perry EK, Perry RH, McKeith IG, Fairbairn AF, Thompson P

Publication type: Article

Publication status: Published

Journal: Neuroscience Research Communications

Year: 1994

Volume: 14

Issue: 1

Pages: 17-25

Print publication date: 01/01/1994

ISSN (print): 0893-6609

ISSN (electronic): 1520-6769

Publisher: John Wiley & Sons Ltd

Share