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Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease

Lookup NU author(s): Emeritus Professor Elaine Perry, Dr Michael Griffiths, Professor Ian McKeith, Emeritus Professor Robert Perry


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ACTIVITY of the enzyme which synthesizes acetylcholine, choline acetyltransferase, was estimated in the neocortex of three series of control and demented cases. Clinically demented cases were divided into those with the classical neuropathological features of Alzheimer's disease (numerous neocortical plaques and tangles) and those with Lewy bodies in the brain stem and cortex (together with plaques and variable neurofibrillary pathology). In the Lewy body cases neocortical choline acetyltransferase was consistently lower than in the classical Alzheimer-type cases. Two of the Lewy body cases with extremely low cholinergic activity were responders in therapeutic trials of the cholinesterase inhibitor, tacrine, and the combined data suggest that cholinergic therapy may be particularly relevant to patients with Lewy body type dementia.

Publication metadata

Author(s): Perry EK, Haroutunian V, Davis KL, Levy R, Lantos P, Eagger S, Honavar M, Dean A, Griffiths M, McKeith IG, Perry RH

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 1994

Volume: 5

Issue: 7

Pages: 747-749

Print publication date: 01/03/1994

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00001756-199403000-00002


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