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Gender differences in the phenotypic expression of Alzheimer's disease in Down's syndrome (Trisomy 21)

Lookup NU author(s): Dr Stephen Tyrer, Emeritus Professor Elaine Perry, Emeritus Professor Robert Perry


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TWENTY-EIGHT individuals with typical Down's syndrome (DS) phenotype (17 males and 11 females; age range: 10-74 years) were investigated for gender differences in the phenotypic expression of Alzheimer-type pathology (ATP). Quantitative neuropathology was performed in the 4 neocortical lobes of the right hemisphere, by counting senile plaques (SP), and neurofibrillary tangles (NFT). ATP was present in 25 middle-aged (> 40 years) individuals (16 males and 9 females). Females had significantly higher (p = 0.03) mean neocortical NFT densities (36.6 per mm(2); s.e.m. +/- 6.6) than males (17.9 per mm(2); s.e.m. +/-: 4.7). None of the females had NFT densities below 10 per mm(2), compared with 6 males in whom NFT were either absent or seen in very low densities (

Publication metadata

Author(s): Raghavan R, Khinnu C, Brown AG, Day KA, Tyrer SP, Ince PG, Perry EK, Perry RH

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 1994

Volume: 5

Issue: 11

Pages: 1393-1396

Print publication date: 27/06/1994

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins