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Discrimination of spermidine amino functions by a new protecting group strategy; application to the synthesis of guanidinylated polyamines, including hirudonine

Lookup NU author(s): Emeritus Professor Bernard Golding, Professor Roger Griffin


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Agmatine and hirudonine, guanidine derivatives of putrescine and spermidine, respectively, are synthesised by the application of a new protecting group strategy for polyamines, which uses N-nitroguanidinyl as a precursor of guanidine functions and selectively blocks spermidine at N-1 and N-8 with trifluoroacetyl and at N-4 by 4-azidobenzyloxycarbonyl.

Publication metadata

Author(s): Mitchinson A, Golding BT, Griffin RJ, O'Sullivan MC

Publication type: Article

Publication status: Published

Journal: Journal of The Chemical Society. Chemical Communications

Year: 1994

Issue: 22

Pages: 2613-2614

Print publication date: 01/11/1994

ISSN (print): 0022-4936

ISSN (electronic): 1364-548X


DOI: 10.1039/C39940002613


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