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The comparative pharmacokinetics and pharmacodynamics of cisplatin and carboplatin in pediatric patients: A review.

Lookup NU author(s): Professor Alan Boddy, Professor Andrew Pearson, Dr Michael Tilby, Professor Herbie Newell


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Cisplatin and carboplatin are important drugs in the treatment of childhood cancels. Extensive data for carbahaline, and more limited results with cisplatin, indicate that there is significant inter-patient pharmacokinetic variability such that adaptive dosing may be necessary for the optimal use of these drugs. Glomerular filtration rate based dosing formulae have been developed for carboplatin and their use is reviewed. Further studies are needed with cisplatin in order to define the reasons for inter-patient pharmacokinetic variability and its relevance in clinical practice. Only very limited data are available on the clinical or molecular pharmacodynamics of cisplatin and carboplatin in paediatric patients. By analogy with adult studies, pharmacologically-guided platinum complex treatment should offer significant advances over empiric dosing.

Publication metadata

Author(s): Bin, P., Boddy, A. V., English, M. W., Pearson, A. D. J., Price, L., Tilby, M. J., Newell, D. R.

Publication type: Article

Publication status: Published

Journal: Anticancer Research

Year: 1994

Volume: 14

Issue: 6A

Pages: 2279-2283

Print publication date: 01/11/1994

ISSN (print): 0250-7005

ISSN (electronic): 1791-7530