Toggle Main Menu Toggle Search

Open Access padlockePrints

A randomized controlled clinical study to quantify the effect of small changes in the design of pacing electrodes on threshold voltages

Lookup NU author(s): Emeritus Professor Alan MurrayORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


A double-blind randomized study of three pacing leads, identical in all ways except for the surface of their electrodes, is presented. The leads were implanted in 30 patients. Ten patients (Group A) received a standard Laserdish lead (dish electrode with laser pores), 10 patients (Group B) received a platinum-iridium coated modified Laserdish electrode, and 10 patients (Group C) received a platinum-iridium coated dish electrode identical to that in Group B except for the absence of laser pores. All leads were implanted by the same operator via the subclavian vein and all patients received an Optima MPT pulse generator. Direct measurement at implantation of pacing threshold and endocardial electrograms showed no significant difference between the three groups (mean +/- standard deviation voltage thresholds 0.30 +/- 0.06 V at 0.5 ms and 0.21 +/- 0.05 V at 1.0-ms pulse durations, R wave amplitude 7.6 +/- 3.2 mV). Significant differences (P = 0.001) were found in threshold impedances at implant (Group A 940 Ohm, Group B 782 Ohm, Group C 673 Ohm). Ten further measurements of voltage threshold were made over the next 2 years. Overall, at a pulse duration of 1.0 ms, a significantly reduced (P

Publication metadata

Author(s): Murray A, Jameson S, Gold RG

Publication type: Article

Publication status: Published


Year: 1995

Volume: 18

Issue: 12

Pages: 2150-2154

Print publication date: 01/12/1995

ISSN (print):

ISSN (electronic):