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Phase I trials in paediatric oncology - The European perspective - On behalf of the new agents group of the United Kingdom Childrens Cancer Study Group

Lookup NU author(s): Professor Herbie Newell, Professor Andrew Pearson


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The current recommendations for Phase I trials should allow more confident interpretation of the toxicity and efficacy of new agents by providing a framework for multicentre and international co-operation. An overview of the aims and designs of Phase I trials is presented, along with a summary of current and recently published United Kingdom Childrens Cancer Study Group Phase I trials, and a discussion of some of the difficulties faced in the methodology and evaluation of Phase I studies in children.

Publication metadata

Author(s): Estlin EJ, Ablett S, Newell DR, Lewis IJ, Lashford L, Pearson ADJ

Publication type: Article

Publication status: Published

Journal: Investigational New Drugs

Year: 1996

Volume: 14

Issue: 1

Pages: 23-32

ISSN (print): 0167-6997

ISSN (electronic): 1573-0646


DOI: 10.1007/BF00173679

PubMed id: 8880390


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