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Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child

Lookup NU author(s): Professor Roderick Skinner, Emeritus Professor Alan Craft, Professor Andrew Pearson


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Although reversibility of acute ifosfamide induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity. (C) 1997 Wiley-Liss, Inc.

Publication metadata

Author(s): Ashraf, M. S., Skinner, R., English, M. W., Craft, A. W., Pearson, A. D. J.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 1997

Volume: 28

Issue: 1

Pages: 62-64

Print publication date: 01/01/1997

ISSN (print): 0098-1532

ISSN (electronic): 1096-911X


DOI: 10.1002/(SICI)1096-911X(199701)28:1<62::AID-MPO12>3.0.CO;2-C

PubMed id: 8950339


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