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Childhood respiratory illness and lung function at ages 14 and 50 years: childhood respiratory illness and lung function

Lookup NU author(s): Peter Tennant, Professor Louise Parker, Professor Mark PearceORCiD


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Background Although childhood respiratory tract infections and low birth weight have both been associated with reduced adult lung function, little is known about the timing of these associations during life. We used data from the Newcastle Thousand Families Study, to examine how these, and other, factors influenced forced expiratory volume in the first second (FEV1) at age 14 years and between ages 14 and 49-51 years. Methods Detailed information was collected prospectively during childhood. At aged 14 years, 252 members of the cohort were recruited into a case-control study of respiratory health, which included measurement of FEV1. 122 of these were measured again at aged 49-51. Linear regression models were used to examine cross-sectional and longitudinal influences on FEV1. Results Lower height (p1 at age 14 years. Correspondingly, being female (p1 at age 14 years (p1 between ages 14 and 49-51 years. Conclusion This study suggests that the change in FEV1 between youth and middle age depends on several factors acting throughout life including FEV1 in adolescence, sex, cigarette smoking history, birth weight, and childhood respiratory health.

Publication metadata

Author(s): Tennant PWG, Gibson GJ, Parker L, Pearce MS

Publication type: Article

Publication status: Published

Journal: Chest

Year: 2010

Volume: 137

Issue: 1

Pages: 146-155

ISSN (print): 0012-3692

ISSN (electronic): 1931-3543

Publisher: American College of Chest Physicians


DOI: 10.1378/chest.09-0352

PubMed id: 19581355


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