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Lookup NU author(s): Professor Kevin Marchbank,
Professor Claire Harris
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The complement system, a pillar of innate immunity, has belatedly become recognised as a key modulator of adaptive immunity, acting to direct, modulate and modify the responses of lymphocytes to stimuli. These effects are mediated by interactions between complement components or activation-derived fragments and specific binding proteins--complement receptors and regulators--on the target cells. This review will describe the current state of knowledge in this swiftly moving field. It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity.
Author(s): Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM
Publication type: Article
Publication status: Published
Journal: Immunology Letters
ISSN (print): 0165-2478
ISSN (electronic): 1879-0542
Publisher: Elsevier BV
Notes: 0165-2478 (Print)
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