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Complement: central to innate immunity and bridging to adaptive responses

Lookup NU author(s): Professor Kevin Marchbank, Professor Claire Harris


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The complement system, a pillar of innate immunity, has belatedly become recognised as a key modulator of adaptive immunity, acting to direct, modulate and modify the responses of lymphocytes to stimuli. These effects are mediated by interactions between complement components or activation-derived fragments and specific binding proteins--complement receptors and regulators--on the target cells. This review will describe the current state of knowledge in this swiftly moving field. It is hoped that the recognition of these properties will help to establish complement in the role it richly deserves as the lynchpin of immunity.

Publication metadata

Author(s): Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM

Publication type: Article

Publication status: Published

Journal: Immunology Letters

Year: 2005

Volume: 97

Issue: 2

Pages: 171-179

ISSN (print): 0165-2478

ISSN (electronic): 1879-0542

Publisher: Elsevier BV


DOI: 10.1016/j.imlet.2004.11.010

Notes: 0165-2478 (Print) Journal Article Review


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