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e-Science: relieving bottlenecks in large-scale genome analyses

Lookup NU author(s): Tracy Craddock, Professor Colin Harwood, Dr Jennifer Hallinan, Professor Anil Wipat


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The development of affordable, high-throughput sequencing technology has led to a flood of publicly available bacterial genome-sequence data. The availability of multiple genome sequences presents both an opportunity and a challenge for microbiologists, and new computational approaches are needed to extract the knowledge that is required to address specific biological problems and to analyse genomic data. The field of e-Science is maturing, and Grid-based technologies can help address this challenge.

Publication metadata

Author(s): Craddock T, Harwood CR, Hallinan J, Wipat A

Publication type: Article

Publication status: Published

Journal: Nature Reviews in Microbiology

Year: 2008

Volume: 6

Issue: 12

Pages: 948-954

ISSN (print): 1740-1526

ISSN (electronic): 1740-1534

Publisher: Nature Publishing Group


DOI: 10.1038/nrmicro2031

Notes: Craddock, Tracy

Harwood, Colin R

Hallinan, Jennifer

Wipat, Anil

Research Support, Non-U.S. Gov't



Nature reviews. Microbiology

Nat Rev Microbiol. 2008 Dec;6(12):948-54.


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Funder referenceFunder name
Physical Sciences Research Council and Non- linear Dynamics
Research Councils UK
UK Engineering
LSH-2002-1.1.0-1European Union