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Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

Lookup NU author(s): Dr Glyn NelsonORCiD


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Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

Publication metadata

Author(s): Nelson DE, Horton CA, See V, Johnson JR, Nelson G, Spiller DG, Kell DB, White MRH

Publication type: Note

Publication status: Published

Journal: Science

Year: 2005

Volume: 308

Issue: 5718

Pages: 52

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203


DOI: 10.1126/science.1108198

Notes: 914IQ Times Cited:0 Cited References Count:16