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Oscillations in transcription factor dynamics: a new way to control gene expression

Lookup NU author(s): Dr Glyn NelsonORCiD

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Abstract

oscillations in second-messenger signalling (e.g. calcium) have previously been shown to be important in the control of transcription. More recently, oscillations in localization and absolute levels of transcription factors and their regulators have been identified. Here we discuss the role of network motifs such as the negative feedback loop and their role in oscillatory signalling, and how oscillations in components of the nuclear factor kappaB signalling pathway are important to the dynamic control of transcription in response to a cytokine stimulus.

Publication metadata

Author(s): Nelson DE, See V, Nelson G, White MRH

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2004

Volume: 32

Issue: 6

Pages: 1090-1092

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: .http//dx.doi.org/10.1042/BST0321090

DOI: 10.1042/BST0321090

Notes: Part 6 878CL Times Cited:11 Cited References Count:15

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