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Medullary autonomic pathology in carotid sinus hypersensitivity

Lookup NU author(s): Veronica Miller, Professor Rose Anne Kenny, Janet Slade, Arthur Oakley, Professor Raj Kalaria

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Abstract

Aims: Carotid sinus hypersensitivity (CSH) is an ageing-related autonomic disorder, rarely occurring before the age of 50 years but increasing in incidence thereafter. Clinical symptoms of CSH include falls and dizziness, thought to be precipitated by dysfunctional baroreflex responses. CSH is highly prevalent in Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB); diseases that are associated with variable degeneration of medullary autonomic nuclei which regulate baroreflex responses. Currently, there are no descriptions of the integrity of medullary autonomic nuclei in CSH. We hypothesized medullary autonomic degeneration is found in elderly patients with CSH. Methods: Using in vitro digital imaging, we quantified the burden of tau, amyloid beta and alpha-synuclein in autonomic nuclei of 12 patients prospectively assessed with CSH (age 83 years) compared with 14 (80 years) control subjects. Results: We found increased tau (P


Publication metadata

Author(s): Miller VM, Kenny RA, Slade JY, Oakley AE, Kalaria RN

Publication type: Article

Publication status: Published

Journal: Neuropathology and Applied Neurobiology

Year: 2008

Volume: 34

Issue: 4

Pages: 403-411

ISSN (print): 0305-1846

ISSN (electronic): 1365-2990

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2990.2007.00903.x

DOI: 10.1111/j.1365-2990.2007.00903.x


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Funding

Funder referenceFunder name
G0500247Medical Research Council
G0400074Medical Research Council
G0502157Medical Research Council

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