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Lookup NU author(s): Emeritus Professor Roger Francis
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Osteoporosis and osteoporotic fractures are generally considered to mainly affect older postmenopausal women, but up to 20% of symptomatic vertebral fractures and 30% of hip fractures occur in men. Osteoporotic fractures in men arc, associated with substantial morbidity greater excess mortality than in women and account for almost 25% of the cost of osteoporotic fractures in the UK. One of the major secondary causes of osteoporosis in men is hypogonadism, which is found in up to 20% of men with symptomatic vertebral fractures and 50% of elderly men with hip fractures. 1 his chapter outlines the pathogenesis of osteoporosis in men, placing particular emphasis on the importance of sex steroids in the maintenance of bone health. The effects of hypogonadism on the skeleton are described, as well as the consequences of androgen deprivation therapy in men with prostate cancer. Finally, we review the effects of testosterone replacement in hypogonadism and explore other options for the treatment of osteoporosis secondary to loss of sex steroids in men. Copyright (C) 2009 S. Karger AG, Basel
Author(s): Tuck SP, Francis RM
Editor(s): Jones, TH; Grossman, AB
Publication type: Book Chapter
Publication status: Published
Book Title: Advances in the Management of Testosterone Deficiency
Year: 2009
Volume: 37
Pages: 123-132
Print publication date: 01/01/2009
Series Title: Frontiers of Hormone Research
Publisher: Karger
Place Published: Switzerland
Library holdings: Search Newcastle University Library for this item
ISBN: 9783805586221
