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Non-invasive quantification of peripheral arterial volume distensibility and its non-linear relationship with arterial pressure

Lookup NU author(s): Dr Ding Chang Zheng, Emeritus Professor Alan MurrayORCiD


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Arterial wall function is associated with different physiological and clinical factors. Changes in arterial pressure cause major changes in the arterial wall. This study presents a simple non-invasive method to quantify arterial volume distensibility changes with different arterial pressures. The electrocardiogram, finger and ear photoplethysmogram were recorded from 15 subjects with the right arm at five different positions (90 degrees, 45 degrees, 0 degrees, -45 degrees and -90 degrees referred to the horizontal level). Arm pulse propagation time was determined by subtracting ear pulse transit time from finger pulse transit time, and was used to obtain arterial volume distensibility. The mean arterial blood pressure with the arm at the horizontal level was acquired, and changes with position were calculated using the hydrostatic principle that blood pressure in the arm is linearly related to its vertical distance from the horizontal level. The mean arm pulse propagation times for the five different positions were 88, 72, 57, 54 and 52 ms, with the corresponding mean arterial volume distensibility of 0.234%, 0.158%, 0.099%, 0.088% and 0.083% per mmHg. For all consecutive changes in arm position, arm pulse propagation time and arterial volume distensibility, were significantly different (all probability P

Publication metadata

Author(s): Zheng DC, Murray A

Publication type: Article

Publication status: Published

Journal: Journal of Biomechanics

Year: 2009

Volume: 42

Issue: 8

Pages: 1032-1037

ISSN (print): 0021-9290

ISSN (electronic): 1873-2380

Publisher: Pergamon


DOI: 10.1016/j.jbiomech.2009.02.011


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