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Determination of aortic valve opening time and left ventricular peak filling rate from the peripheral pulse amplitude in patients with ectopic beats

Lookup NU author(s): Dr Ding Chang Zheng, Professor John AllenORCiD, Emeritus Professor Alan MurrayORCiD


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Ectopic beats are common in patients who have heart disease and are associated with reduced peripheral pulse amplitude. This study determined the start of the peripheral pulse increase and from it the opening of the aortic valve. The left ventricular peak filling rate was also estimated from the peripheral pulse. Results were compared with published invasive and cardiac imaging data. Twenty-five subjects with ectopic beat electrocardiograms (ECGs) were studied. The ECGs and the peripheral pulses, detected optically at the right index finger by a simple photoplethysmography (PPG) technique, were recorded for subsequent analysis. Peripheral pulse amplitudes for ectopic beats, post-ectopic sinus beats and normal sinus beats were determined. Ectopic beats induced a mean 68% decrease in pulse amplitude in comparison with sinus beats (p

Publication metadata

Author(s): Zheng D, Allen J, Murray A

Publication type: Article

Publication status: Published

Journal: Physiological Measurement

Year: 2008

Volume: 29

Issue: 12

Pages: 1411-1419

ISSN (print): 0967-3334

ISSN (electronic): 1361-6579

Publisher: Institute of Physics Publishing Ltd.


DOI: 10.1088/0967-3334/29/12/005


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