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Levodopa Use and Sleep in Patients with Dementia with Lewy Bodies

Lookup NU author(s): Dr Sophie Molloy, Dr Thais Minett, Professor John O'Brien, Professor Ian McKeith, Professor David Burn


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Sleep disturbance and excessive daytime somnolence (EDS) are features of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) that may be influenced by dopamine replacement therapy. The effect of levodopa on sleep and EDS in DLB is unknown and unclear in PD. The aim of, this study is to determine if levodopa treatment alters sleep symptoms and EDS in DLB. Dopamine naive patients with DLB (n = 15: mean mini mental state examination (MMSE) score 17.7(4.6)) and PD (n = 9; mean MMSE 25.5(2.2)) were assessed using the Epworth sleep scale. Parkinson's disease sleep scale. and the neuropsychiatric inventory prior to initiating treatment with levodopa. All measures were repeated after 3 and 6 months of levodopa therapy. The median final daily levodopa dose was 300 mg in both groups. Baseline sleep measures were comparable between groups. Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective steep measures or increase EDS in DLB patients. (C) 2009 Movement Disorder Society

Publication metadata

Author(s): Molloy S, Minett T, O'Brien JT, McKeith IG, Burn DJ

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2009

Volume: 24

Issue: 4

Pages: 609-612

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/mds.22411


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Funder referenceFunder name
G0400074Medical Research Council
G0502157Medical Research Council