ePrints

Cortical Serotonin 1A Receptor Levels Are Associated with Depression in Patients with Dementia with Lewy Bodies and Parkinson's Disease Dementia

Lookup NU author(s): Dr Clive Ballard, Dr Iryna Ziabreva, Dr Margaret Piggott, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry, Dr Dag Aarsland

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Background: Serotonin 1A receptors (5-HT1A) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression. Aim: To examine 5-HT1A in DLB and PDD postmortem in relation to depression. Methods: [H-3]8-hydroxy-2-dipropylaminotetralin binding to 5-HT1A was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. Results: 5-HT1A density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20. Conclusion: Higher BA36 5-HT1A density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT1A antagonist adjuvant may improve treatment of depression in dementia. Copyright (C) 2008 S. Karger AG, Basel

Publication metadata

Author(s): Sharp SI, Ballard CG, Ziabreva I, Piggott MA, Perry RH, Perry EK, Aarsland D, Ehrt U, Larsen JP, Francis PT

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2008

Volume: 26

Issue: 4

Pages: 330-338

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000161058

DOI: 10.1159/000161058

Altmetrics

Share