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Lookup NU author(s): Dr Scott Wilkes, Professor Alison Murdoch, Dr Nick Steen, Dr John Wilsdon, Emeritus Professor Greg RubinORCiD
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Background GPs investigate approximately half of all infertile couples with semen analysis and endocrine blood tests. For assessment of tubal status, hysterosalpingography (HSG) is recommended as a first-line investigation for women not known to have comorbidities. Aim To test whether providing GPs with open access to HSG results in infertile couples progressing to a diagnosis and management plan sooner than with usual management. Design of study A pragmatic cluster randomised controlled trial. Setting Seventy-one of 173 general practices in north-east England agreed to participate. Method A total of 670 infertile couples presented to 33 intervention practices and 25 control practices over a 2-year period. Practices allocated to the intervention group had access to HSG for those infertile women who fulfilled predefined eligibility criteria. The primary outcome measure was the interval between presentation to the GP and the couple receiving a diagnosis and management plan. Results An annual incidence of 0.8 couples per 1000 total population equated to each GP seeing an average of one or two infertile couples each year. Open access HSG was used for 9% of all infertile women who presented to the intervention practices during the study period. The time to reach a diagnosis and management plan for all infertile couples presenting was not affected by the availability-of open access HSG (Cox regression hazard ratio = 0.9, 95% confidence interval [CI] = 0.7 to 1.1). For couples who reached a diagnosis and management plan, there was a non-significant difference in time to primary outcome for intervention versus control practices (32.5 weeks versus 30.5 weeks, mean difference 2.2 weeks, 95% CI = 1.6 to 6.1 weeks, P = 0.1). The intracluster correlation coefficient was 0.03 across all practices. Conclusion Providing GPs with open access to HSG had no effect on the time taken to reach a diagnosis and management plan for couples with infertility.
Author(s): Wilkes S, Murdoch A, Steen N, Wilsdon J, Rubin G
Publication type: Article
Publication status: Published
Journal: British Journal of General Practice
Year: 2009
Volume: 59
Issue: 562
Pages: 329-335
ISSN (print): 0960-1643
ISSN (electronic): 1478-5242
Publisher: Royal College of General Practitioners
URL: http://dx.doi.org/10.3399/bjgp09X420590
DOI: 10.3399/bjgp09X420590
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