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The efficacy of topical hyaluronic acid in the management of oral lichen planus

Lookup NU author(s): Dr Anita Nolan, Emeritus Professor Robin Seymour


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The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) gel preparation (0.2%) in the management of oral lichen planus (OLP). A total of 124 patients with erosive OLP participated in a randomized, placebo-controlled, double-blind trial to evaluate the efficacy of a topical HA preparation. Outcome measures included soreness relief following immediate application, oral function and size of erosive/ulcerative area. Patients were medicated for 28 days and completed a log diary recording oral function and soreness scores. Application of topical HA produced a significant reduction (P 0.05) with respect to oral function. Patients treated with 0.2% HA showed a significant reduction (P

Publication metadata

Author(s): Nolan A, Badminton J, Maguire J, Seymour RA

Publication type: Article

Publication status: Published

Journal: Journal of Oral Pathology & Medicine

Year: 2009

Volume: 38

Issue: 3

Pages: 299-303

ISSN (print): 0904-2512

ISSN (electronic): 1600-0714

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1600-0714.2008.00739.x


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