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A Volumetric Magnetic Resonance Imaging Study of Entorhinal Cortex Volume in Dementia with Lewy Bodies

Lookup NU author(s): Dr Eva Lowther, Dr Emma Burton, Professor John O'Brien

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Abstract

Aims: To investigate whether subjects with dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD) have reduced entorhinal cortex (EC) volumes compared to controls and cognitively intact Parkinson's disease (PD) subjects. Methods: Volumes of the EC were measured on magnetic resonance imaging (MRI) scans of 144 individuals (aged over 65 years): 20 with DLB, 26 with AD, 30 with PDD, 31 with PD and 37 normal age-matched controls. Results: Total normalised EC volumes were significantly smaller in DLB, AD and PDD patients compared to controls, and in DLB and AD patients compared to PD patients (p

Publication metadata

Author(s): Kenny ER, Burton EJ, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2008

Volume: 26

Issue: 3

Pages: 218-225

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000153432

DOI: 10.1159/000153432

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