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Metalloproteins and metal sensing

Lookup NU author(s): Dr Kevin WaldronORCiD, Dr Julian Rutherford, Professor Dianne Ford, Professor Nigel Robinson


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Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.

Publication metadata

Author(s): Waldron KJ, Rutherford JC, Ford D, Robinson NJ

Publication type: Review

Publication status: Published

Journal: Nature

Year: 2009

Volume: 460

Issue: 7257

Pages: 823-830

ISSN (print): 0028-0836

ISSN (electronic): 1476-4687


DOI: 10.1038/nature08300