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Lookup NU author(s): Dr Clive Ballard, Simon Douglas, Professor Philip Bradley, Adam Burns, Professor John O'Brien, Dr Robert Bullock
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Background: Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way. Methods: At the first stage of a randomized blinded placebo-controlled trial, 318 patients with Alzheimer disease (AD) with clinically significant agitated behavior were treated in an open design with a psychological intervention (brief psychosocial therapy [BPST]) for 4 weeks, preceding randomization to pharmacotherapy. The therapy involved social interaction, personalized music, or removal of environmental triggers. Results: Overall, 318 patients with AD completed BPST with an improvement of 5.6 points on the total Cohen-Mansfield Agitation Inventory (CMAI; mean [SD], 63.3 [16.0] to 57.7 [18.4], t = 4.8, df = 317, p 95% of patients. More detailed evaluation of outcome was completed for the 198 patients with AD from these centers, who experienced a mean improvement of 6.6 points on the total CMAI (mean [SD], 62.2 [14.3] to 55.6 [15.8], t = 6.5, df - 197, p
Author(s): Ballard C, Brown R, Fossey J, Douglas S, Bradley P, Hancock J, James IA, Juszczak E, Bentham P, Burns A, Lindesay J, Jacoby R, O'Brien J, Bullock R, Johnson T, Holmes C, Howard R
Publication type: Article
Publication status: Published
Journal: American Journal of Geriatric Psychiatry
Year: 2009
Volume: 17
Issue: 9
Pages: 726-733
ISSN (print): 1064-7481
ISSN (electronic): 1545-7214
Publisher: Lippincott Williams & Wilkins
URL: http://dx.doi.org/10.1097/JGP.0b013e3181b0f8c0
DOI: 10.1097/JGP.0b013e3181b0f8c0
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