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Lookup NU author(s): Ros Brown,
Professor Michael Goodfellow
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The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.
Author(s): Fiedler HP, Dieter A, Guider TAM, Kajahn I, Hamm A, Brown R, Jones AL, Goodfellow M, Muller WEG, Bringmann G
Publication type: Article
Publication status: Published
Journal: Journal of Antibiotics
ISSN (print): 0021-8820
ISSN (electronic): 1881-1469
Publisher: Nature Publishing Group
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