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Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp AK 671

Lookup NU author(s): Ros Brown, Amanda Jones, Professor Michael Goodfellow


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The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

Publication metadata

Author(s): Fiedler HP, Dieter A, Guider TAM, Kajahn I, Hamm A, Brown R, Jones AL, Goodfellow M, Muller WEG, Bringmann G

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2008

Volume: 61

Issue: 7

Pages: 464-473

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group


DOI: 10.1038/ja.2008.63


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