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Differential deficit in executive control in euthymic bipolar disorder

Lookup NU author(s): Jill Thompson, Dr John Gray, Dr John Hughes, Professor Allan Young, Professor Nicol Ferrier

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Abstract

Patients with remitted bipolar disorder (BD) have persistent cognitive deficits, but the nature and specificity of this deficit remain unclear. The authors evaluated the executive hypothesis of BD by determining whether (a) patients' executive deficits qualify as differential deficits, that is, that these significantly exceed deficits in other cognitive domains: (b) deficits in particular executive functions are evident, and (c) executive difficulties mediate declarative memory deficits in BD. The cognitive performance of 63 prospectively verified euthymic bipolar patients was compared with controls, using J. Baron and R. Trieman's 0980) method of testing for differences in nonindependent correlations. There were no differential deficits within the executive domain. Patients' generic executive performance was differentially impaired relative to primary verbal memory and retention in declarative memory, but not relative to their declarative recall, recognition, or their psychomotor performance. However, patients' executive deficit was not an artifact of their poor psychomotor performance. Executive performance accounted for all but a trivial portion of the between-group variance in declarative memory. Persistent cognitive difficulties in euthymic bipolar disorder (EBD) are thus usefully characterized as a deneric dysexecutive syndrome.


Publication metadata

Author(s): Thompson JM, Gray JM, Crawford JR, Hughes JH, Young AH, Ferrier IN

Publication type: Article

Publication status: Published

Journal: Journal of Abnormal Psychology

Year: 2009

Volume: 118

Issue: 1

Pages: 146-160

ISSN (print): 0021-843X

ISSN (electronic): 1939-1846

Publisher: American Psychological Association

URL: http://dx.doi.org/10.1037/a0014740

DOI: 10.1037/a0014740


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