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Bendigoles A~C, New Steroids from Gordonia australis Acta 2299

Lookup NU author(s): Professor Michael Goodfellow

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Abstract

Bendigoles A similar to C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A-C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.

Publication metadata

Author(s): Schneider K, Graf E, Irran E, Nicholson G, Stainsby FM, Goodfellow M, Borden SA, Keller S, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2008

Volume: 61

Issue: 6

Pages: 356-364

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2008.50

DOI: 10.1038/ja.2008.50

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