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Lookup NU author(s): Professor Michael Goodfellow
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Bendigoles A similar to C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A-C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.
Author(s): Schneider K, Graf E, Irran E, Nicholson G, Stainsby FM, Goodfellow M, Borden SA, Keller S, Sussmuth RD, Fiedler HP
Publication type: Article
Publication status: Published
Journal: Journal of Antibiotics
ISSN (print): 0021-8820
ISSN (electronic): 1881-1469
Publisher: Nature Publishing Group
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