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Lookup NU author(s): Professor Alan Bull,
Professor Michael Goodfellow,
Dr Luis Maldonado,
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A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
Author(s): Fiedler HP, Bruntner C, Riedlinger J, Bull AT, Knutsen G, Goodfellow M, Jones A, Maldonado L, Pathom-Aree W, Beil W, Schneider K, Keller S, Sussmuth RD
Publication type: Article
Publication status: Published
Journal: Journal of Antibiotics
ISSN (print): 0021-8820
ISSN (electronic): 1881-1469
Publisher: Nature Publishing Group
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