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The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA

Lookup NU author(s): Dr Jon Marles-WrightORCiD, Professor Rick Lewis


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There are three stages of transcribing DNA into RNA. These stages are initiation, elongation and termination, and they are well-understood biochemically. However, despite the plethora of structural information made available on RNA polymerase in the last decade, little is available for RNA polymerase in complex with transcription elongation factors. To understand the mechanisms of transcriptional regulation, we describe the first structure, to our knowledge, for a bacterial RNA polymerase in complex with an essential transcription elongation factor. The resulting structure formed between the RNA polymerase and NusA from Bacillus subtilis provides important insights into the transition from an initiation complex to an elongation complex, and how NusA is able to modulate transcription elongation and termination.

Publication metadata

Author(s): Yang X, Molimau S, Doherty GP, Johnston EB, Marles-Wright J, Rothnagel R, Hankamer B, Lewis RJ, Lewis PJ

Publication type: Article

Publication status: Unknown

Journal: EMBO Reports

Year: 2009

Volume: 10

Issue: 9

Pages: 997-1002

ISSN (print): 1469-221X

ISSN (electronic): 1469-3178

Publisher: Nature Publishing Group


DOI: 10.1038/embor.2009.155


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Funder referenceFunder name
UK Biotechnology and Biological Sciences Research Council.
DP0664370Australian Research Council
DP0452362Australian Research Council
LX056108Australian Research Council