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Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients

Lookup NU author(s): Dr Andrea Tasker, Dr Clive Ballard, Dr Ed Okello, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry


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There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from three centres: Newcastle, Oxford and London. Mean BuChE activity in temporal cortex was 37% higher in K homozygotes than in wild-type homozygotes. Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p = 0.009). (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Tasker A, Ballard CG, Joachim C, Warden DR, Okello EJ, Perry RH, Khan N, Smith AD, Lehmann DJ, Perry EK

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2008

Volume: 442

Issue: 3

Pages: 297-299

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier


DOI: 10.1016/j.neulet.2008.07.023


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