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Changes in myometrial 'perfusion' during normal labor as visualized by three-dimensional power Doppler angiography

Lookup NU author(s): Professor Michael Taggart

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Abstract

Objectives Myometrial contractions are one of the most important aspects of effective labor. For cells within the myometrium to work efficiently they need to be well oxygenated and this requires an adequate blood supply. This stud), used quantitative three-dimensional (3D) power Doppler angiography to calculate the percentage change in myometrial blood flow during a relaxation-contraction-relaxation cycle of active labor. Methods Transabdominal 3D power Doppler ultrasound imaging was used to acquire volumetric data during the first stage of spontaneous labor in 20 term, nulliparous women. 3 D datasets were acquired during a single cycle of uterine relaxation, contraction and subsequent relaxation for each subject. The resultant datasets were analyzed independently by two investigators on two occasions using Virtual Organ Computer-aided AnaLysis to define a volume of interest within the myometrium; the power Doppler signal within this volume was quantified to provide 3D indices of vascularity: vascularization index (VI), flow index (FT) and vascularization flow index (VFI). The percentage change in these indices, during a uterine contraction, was calculated from the baseline value during the initial uterine relaxation phase (taken as a maximum of 100%). Results Myometrial blood flow fell significantly during the uterine contraction and returned during the subsequent relaxation phase of the cycle (P


Publication metadata

Author(s): Jones NW, Raine-Fenning NJ, Jayaprakasan K, Mousa HA, Taggart MJ, Bugg GJ

Publication type: Article

Publication status: Published

Journal: Ultrasound in Obstetrics and Gynecology

Year: 2009

Volume: 33

Issue: 3

Pages: 307-312

ISSN (print): 0960-7692

ISSN (electronic): 1469-0705

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/uog.6303

DOI: 10.1002/uog.6303


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