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Highly Enantioselective Synthesis of Pseudo-C2-Symmetric Axially Chiral Biaryl Diphosphines via Rhodium-Catalyzed Double [2 + 2 + 2] Cycloaddition

Lookup NU author(s): Dr Simon DohertyORCiD, Catherine Smyth, Dr Ross Harrington, Emeritus Professor Bill CleggORCiD


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Cationic rhodium complexes based on (R)-BINAP catalyze the sequential double [2 + 2 + 2] cycloaddition between 1,4-bis(diphenylphosphinoyl)buta-1,3-diyne and an internal 2,n-diyne followed by its terminal counterpart in an operationally straightforward procedure to afford pseudo-C-2-symmetric axially chiral biaryl diphosphines in good yield and with exceptionally high enantioselectivity.

Publication metadata

Author(s): Doherty S, Smyth CH, Harrington RW, Clegg W

Publication type: Article

Publication status: Published

Journal: Organometallics

Year: 2008

Volume: 27

Issue: 19

Pages: 4837-4840

ISSN (print): 0276-7333

ISSN (electronic): 1520-6041

Publisher: American Chemical Society


DOI: 10.1021/om800755x


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