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Lookup NU author(s): Professor Michael North
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A number of polydentate ligands based on enantiomerically pure binaphthol have been synthesized. The ligand complexes with titanium isopropoxide were used as catalysts for the asymmetric addition of trimethylsilyl cyanide to benzaldehyde. A fragment with axial chirality is responsible for the configuration of O-trimethylsilyl cyanohydrin product. In the case of the optimum ligand based on (R)-binaphthol and (S)-leucinol, an enantiomeric excess of 86% and quantitative yield were achieved in 4 h.
Author(s): Belokon YN, Chusov DA, Skrupskaya TV, Bor'kin DA, Yashkina LV, Lyssenko KA, Il'in MM, Strelkova TV, Timofeeva GI, Peregudov AS, North M
Publication type: Article
Publication status: Published
Journal: Russian Chemical Bulletin
ISSN (print): 1066-5285
ISSN (electronic): 1573-9171
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