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A bimetallic aluminium(salen) complex for asymmetric cyanohydrin synthesis

Lookup NU author(s): Professor Michael North

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Abstract

In the presence of a phosphine oxide cocatalyst, a bimetallic aluminium(salen) complex was found to catalyse the asymmetric addition of trimethylsilyl cyanide to aldehydes. Under optimised conditions, enantioselectivities of 53-96% were obtained using 2 mol% of the catalyst. An analysis of the reaction kinetics showed that the reactions exhibited first-order kinetics, with the race of reaction being independent of the aldehyde concentration. (C) 2009 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): North M, Williamson C

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 2009

Volume: 50

Issue: 26

Pages: 3249-3252

Date deposited: 21/10/2009

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.tetlet.2009.02.028

DOI: 10.1016/j.tetlet.2009.02.028

Notes: 50th Anniversary Special Issue

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