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Lookup NU author(s): Professor Raj KalariaORCiD, Emeritus Professor Elaine Perry, Dr Martin Prince
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Despite mortality due to communicable diseases, poverty, and human conflicts, dementia incidence is destined to increase in the developing world in tandem with the ageing population. Current data from developing countries suggest that age-adjusted dementia prevalence estimates in 65 year olds are high (>= 5%) in certain Asian and Latin American countries, but consistently low (1-3%) in India and sub-Saharan Africa; Alzheimer's disease accounts for 60% whereas vascular dementia accounts for similar to 30% of the prevalence. Early-onset familial forms of dementia with single-gene defects occur in Latin America, Asia, and Africa. Illiteracy remains a risk factor for dementia. The APOE epsilon 4 allele does not influence dementia progression in sub-Saharan Africans. Vascular factors, such as hypertension and type 2 diabetes, are likely to increase the burden of dementia. Use of traditional diets and medicinal plant extracts might aid prevention and treatment. Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions.
Author(s): Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall KT, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P, World Federation Neurology Dement
Publication type: Review
Publication status: Published
Journal: The Lancet Neurology
Year: 2008
Volume: 7
Issue: 9
Pages: 812-826
ISSN (print): 1474-4422
ISSN (electronic): 1474-4465
Publisher: ELSEVIER SCIENCE INC
URL: http://dx.doi.org/10.1016/S1474-4422(08)70169-8
DOI: 10.1016/S1474-4422(08)70169-8
