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Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

Lookup NU author(s): Professor Raj KalariaORCiD, Emeritus Professor Elaine Perry, Dr Martin Prince


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Despite mortality due to communicable diseases, poverty, and human conflicts, dementia incidence is destined to increase in the developing world in tandem with the ageing population. Current data from developing countries suggest that age-adjusted dementia prevalence estimates in 65 year olds are high (>= 5%) in certain Asian and Latin American countries, but consistently low (1-3%) in India and sub-Saharan Africa; Alzheimer's disease accounts for 60% whereas vascular dementia accounts for similar to 30% of the prevalence. Early-onset familial forms of dementia with single-gene defects occur in Latin America, Asia, and Africa. Illiteracy remains a risk factor for dementia. The APOE epsilon 4 allele does not influence dementia progression in sub-Saharan Africans. Vascular factors, such as hypertension and type 2 diabetes, are likely to increase the burden of dementia. Use of traditional diets and medicinal plant extracts might aid prevention and treatment. Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions.

Publication metadata

Author(s): Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall KT, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P, World Federation Neurology Dement

Publication type: Review

Publication status: Published

Journal: The Lancet Neurology

Year: 2008

Volume: 7

Issue: 9

Pages: 812-826

ISSN (print): 1474-4422

ISSN (electronic): 1474-4465



DOI: 10.1016/S1474-4422(08)70169-8