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Lookup NU author(s): Armin Rashidi,
Emeritus Professor Thomas Kirkwood,
Dr Daryl Shanley
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The lack of an effective antioxidant system in beta-cells, which renders them susceptible to oxidative stress, is to date without explanation. The particular weakness of beta-cells in females, in both humans and mice, is another unexplained observation. We hypothesise that reactive oxygen species (ROS) in beta-cells, by their negative effect on insulin synthesis/secretion, play a fitness-enhancing role for the whole organism. Under stress conditions, the release of stress hormones produces insulin resistance and, owing to ROS preventing beta-cells from secreting insulin at the level required to maintain homeostasis, diverts glucose to insulin-independent tissues such as the brain and the foetus. We suggest that pancreatic beta-cells lost part of their antioxidant defence in association with brain evolution, and lost even more in females when placental mammals evolved. The unusual antioxidant status of beta-cells may thus be explained as an instance of co-evolution of the brain, cortisol and corticosteroid receptors, and beta-cells in the endocrine pancreas. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Author(s): Rashidi A, Kirkwood TBL, Shanley DP
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier Ireland Ltd.
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