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Lookup NU author(s): Professor John Robinson
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An in vitro model for the study of T-cell ontogeny is presented. The generation of mitogen responsive thymocytes in embryonic mouse thymus using an organ culture system is described. The pattern of development of mitogen responsiveness in vitro is similar to that seen in vivo except that responses were greater and appeared later in culture than in thymus of a temporally equivalent age in vivo. This suggests that organ culture selectively enriches T-cell activity and thus offers a novel approach to the analysis of T-cell reactivity as well as to the understanding of defects in T-cell development.
Author(s): Robinson JH, Owen JJT
Publication type: Article
Publication status: Published
Journal: Journal of Immunology
ISSN (print): 0022-1767
ISSN (electronic): 1550-6606
Publisher: American Association of Immunologists
Notes: Reprint from Clinical and Experimental Immunology, 1976, 23: 347–354