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Pillars of Immunology article: Generation of T-cell Function in Organ Culture of Foetal Mouse Thymus. I. Mitogen Responsiveness

Lookup NU author(s): Professor John Robinson


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An in vitro model for the study of T-cell ontogeny is presented. The generation of mitogen responsive thymocytes in embryonic mouse thymus using an organ culture system is described. The pattern of development of mitogen responsiveness in vitro is similar to that seen in vivo except that responses were greater and appeared later in culture than in thymus of a temporally equivalent age in vivo. This suggests that organ culture selectively enriches T-cell activity and thus offers a novel approach to the analysis of T-cell reactivity as well as to the understanding of defects in T-cell development.

Publication metadata

Author(s): Robinson JH, Owen JJT

Publication type: Article

Publication status: Published

Journal: Journal of Immunology

Year: 2008

Volume: 181

Issue: 11

Pages: 7437-7444

ISSN (print): 0022-1767

ISSN (electronic): 1550-6606

Publisher: American Association of Immunologists


Notes: Reprint from Clinical and Experimental Immunology, 1976, 23: 347–354