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Network Motifs in Context: An Exploration of the Evolution of Oscillatory Dynamics in Transcriptional Networks

Lookup NU author(s): Dr Jennifer Hallinan, Professor Anil Wipat


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The concept of a network motif-a small set of interacting genes which produce a predictable behaviour at the network level-has attracted considerable attention amongst network analysts. It is of particular interest to synthetic biology, a new discipline which aims to apply engineering principles to biological systems. The modular nature of network motifs would make them ideal candidates for the basic components of an engineered organism. In this paper we investigate the relationship between the presence of network motifs and oscillatory dynamics in a yeast transcriptional network and a set of computational networks, evolved to exhibit oscillatory behaviour. Our results do not support the hypothesis that network motifs are critical to network dynamics, possibly because they are tightly connected to many other components of the complex cell-wide transcriptional network.

Publication metadata

Author(s): Hallinan JS, Wipat A

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology

Year of Conference: 2008

Pages: 83-89

Publisher: IEEE


DOI: 10.1109/CIBCB.2008.4675763

Library holdings: Search Newcastle University Library for this item

ISBN: 9781424417780