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Autonomic dysfunction in chronic liver disease

Lookup NU author(s): Dr James FrithORCiD, Emerita Professor Julia Newton


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Autonomic dysfunction (AD) is common in chronic liver disease (CLD) of all aetiologies and even more so in those awaiting transplantation. As yet, the pathophysiology is not completely understood but the clinical effects are dramatic for the patient, who has a heavy symptomatic burden. There are several considerations, specific to liver disease, which complicate AD. Outlined here is a practical guide for clinicians detailing the common presentations and consequences of AD, investigation techniques and treatment options. As morbidity and mortality is increased in CLD patients with AD its recognition, investigation and management is important to all who encounter such patients.

Publication metadata

Author(s): Frith J, Newton JL

Publication type: Review

Publication status: Published

Journal: Liver International

Year: 2009

Volume: 29

Issue: 4

Pages: 483-489

ISSN (print): 1478-3223

ISSN (electronic): 1478-3231



DOI: 10.1111/j.1478-3231.2009.01985.x