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Nitrosative and oxidative stress responses in fungal pathogenicity

Lookup NU author(s): Professor Janet Quinn

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Abstract

Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.

Publication metadata

Author(s): Brown AJP, Haynes K, Quinn J

Publication type: Review

Publication status: Published

Journal: Current Opinion in Microbiology

Year: 2009

Volume: 12

Issue: 4

Pages: 384-391

ISSN (print): 1369-5274

ISSN (electronic):

Publisher: CURRENT BIOLOGY LTD

URL: http://dx.doi.org/10.1016/j.mib.2009.06.007

DOI: 10.1016/j.mib.2009.06.007

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