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Recognition of deaminated bases by archaeal family-B DNA polymerases

Lookup NU author(s): Professor Bernard Connolly


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Archaeal family-B DNA polymerases interact specifically with uracil and hypoxanthine, stalling replication on encountering these deaminated bases in DNA template strands. The present review describes X-ray structural data which elucidate the mechanism of read-ahead recognition of uracil and suggests how this is coupled to cessation of polymerization. The possible role of read-ahead recognition of uracil/hypoxanthine in DNA repair is discussed, as is the observation that the feature appears to be limited to replicative polymerases of the archaeal domain.

Publication metadata

Author(s): Connolly BA

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: Conference on Molecular Biology of Archaea

Year of Conference: 2009

Pages: 65-68

ISSN: 0300-5127

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0370065

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752